Background: The therapeutic development of pregnane X receptor (PXR) agonists for ulcerative colitis (UC) is hindered by the poor selectivity of the canonical ligand-binding pocket. This study aimed ...

Publisher Nicalis and developer Edmund McMillen announced The Binding of Isaac: Repentance+ will launch for the Nintendo Switch 2 in Q1 2026. A physical edition will be available for $69.99 on the ...

Dr. James McCaffrey presents a complete end-to-end demonstration of linear regression with two-way interactions between predictor variables. Standard linear regression predicts a single numeric value ...

This June, Shohei Ohtani stepped onto the mound for the first time in 21 months. Two minutes after recording the final out of the first inning, he dug into the batter’s box to lead off for the Los ...

Where have all the two-way players gone? That was the thesis of an article published Tuesday in The Athletic, which held a microscope to the many pitcher-slash-position-players to reach the minor ...

Two-way contracts allow NBA teams to carry three extra players in addition to the 15 on their regular season roster. These players generally bounce back and forth between the NBA and G League, but ...

Boltz-2 is the first biomolecular co-folding model to combine structure and binding affinity prediction, approaching the accuracy of physics-based free energy perturbation (FEP) calculations but at ...

Louisville is converting several one-way streets to two-way streets to improve safety and traffic flow. Completed conversions include portions of South Fifth, West Oak and East Jefferson streets, as ...